Set up your virtual host as shown below. Also enable the module proxy_wstunnel
ProxyRequests On ProxyPreserveHost On ProxyPassMatch ^/_blazor/(.*) http://0.0.0.0:5001/_blazor/$1 ProxyPass /_blazor ws://localhost:5001/_blazor ProxyPass / http://0.0.0.0:5001/ ProxyPassReverse / http://0.0.0.0:5001/